Cardiac surgery has resulted in a reduced postoperative cardiac morbidity. It may be worthwhile establishing this technique, SKF 38393 hydrobromide unless contraindicated, in such patients.P435 Addition of propofol, midazolam, or haloperidol to sufentanil for intravenous sedation in the ICU using the bispectral indexB Tukenmez, D Memis, Z Pamukcu Trakya University, Edirne, Turkey Critical Care 2006, 10(Suppl 1):P435 (doi: 10.1186/cc4782) Objective Inadequate sedative techniques may adversely affect morbidity and mortality in the ICU, and the search for the ideal sedative agent continues. Combinations of hypnotics and opiates have become commonly used for sedation. In our study, we aimed to assess whether the addition of propofol, midazolam, or haloperidol infusion decreased or not the sufentanil requirements using the bispectral index (BIS). Materials and methods The study was planned in 60 ICU patients. All patients received 0.5 mg/kg sufentanil i.v. bolus. Immediately after, Group S received 0.25 mg/kg sufentanil infusion, Group SP received sufentanil infusion + propofol 25 mg/kg/min infusion, Group SM received sufentanil infusion + midazolam 0.04 mg/kg/hour infusion, and Group SH received sufentanil infusion + haloperidol 3 mg/kg/hour infusion for 6 hours. Average BIS values were kept in the range of 61?0 by decreasing or increasing sufentanil levels in all groups, and hourly sufentanil consumption was determined. Hemodynamic, biochemical parameters, and arterial blood gases were determined at baseline, and were repeated in study hours. Results There was no significant difference in hemodynamic and biochemical parameters and arterial blood gases among the groups. Propofol, midazolam, and haloperidol infusion, when added to sufentanil infusion, decreased the consumption of sufentanil in all the measured times (P < 0.001). Conclusion We aimed to determine the effect of propofol, midazolam, or haloperidol infusion when added to sufentanil infusion in a sPubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/2878751PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/2878751 ID:https://www.ncbi.nlm.nih.gov/pubmed/21804710 influence of multiple organ dysfunctions and old age on the dosage and duration of RF infusion in critically ill patients. Methods Set in a general surgical ICU of a university hospital. Within 28 months, 876 postoperative patients requiring ventilation received analgo-sedation with a constant low-dose propofol infusion (1.5 mg/kg/hour) and a variable continuous RF infusion to a target Ramsay Sedation Score 2?, until either ventilatory withdrawal was initiated or sedation regimen was changed after 48 hours. The hourly dosage and total duration of RF infusion, and the SOFA score were documented. Potential predictors for RF dosage were evaluated by univariate and subsequent stepwise multiple regression analysis. Significance was set at P < 0.05. Results The median ( QR) SOFA score was 7 ?4, infusion duration 16 ?12 hours, age 70 ?29 years, mean ( D) RF dosage 87 ?44 ng/kg/min. Neither the total SOFA score or any single composite organ dysfunction influenced the dosage of RF infusion (Table 1). However, older patients needed considerably smaller RF dosages. Patients with multiple organ dysfunction had prolonged infusion duration, but no change in dosage. After discontinuation of RF infusion, all patients were awake and extubated within 1? hours.Table 1 (abstract P436) SOFA score RF dosage Infusion duration P = 0.59 P < 0.001 Renal dysfunction P = 0.11 P = 0.40 Liver dysfunction P.